Oxidant-free dehydrogenative coupling via electrooxidation: a mild, green, and sustainable route to synthesize aryl amines integrated with hydrogen evolution
نویسندگان
چکیده
منابع مشابه
Mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde.
A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.
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The direct oxidative cross-dehydrogenative coupling (CDC) of two C H bonds can be an efficient and relatively clean strategy in organic synthesis. Various sp C Hbonds, such as benzylic and allylic C H bonds, the a-C H bonds of amines and ethers, and the C H bonds of alkanes can be oxidized for direct reaction with carbon nucleophiles. Among these reactions, the oxidation of tertiary amines to g...
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Fluorinated amines, especially b-fluorinated amines, have received much attention in bioorganic and medicinal chemistry research due to the profound change of the basicity of the amine functionality imparted by fluorine substitution, which has dramatic and beneficial influences on the bioavailability of a target molecule. Among various methods for synthesizing fluorinated amines, nucleophilic f...
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A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)(2) and Cs(2)CO(3) has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.
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ژورنال
عنوان ژورنال: Science Bulletin
سال: 2018
ISSN: 2095-9273
DOI: 10.1016/j.scib.2018.05.006